Molecular Formula | C30H48O4 |
Molar Mass | 472.7 |
Density | 1.14±0.1 g/cm3(Predicted) |
Melting Point | 297-299 °C(Solv: chloroform (67-66-3); methanol (67-56-1)) |
Boling Point | 586.2±50.0 °C(Predicted) |
Solubility | DMSO, Pyridine, Methanol, Ethanol, etc. |
Appearance | Powder |
pKa | 4.48±0.70(Predicted) |
Storage Condition | 2-8℃ |
MDL | MFCD04039823 |
In vitro study | Randialic acid A (Pomolic acid) induces apoptosis of GBM cells as demonstrated by DNA fragmentation. Pomolic acid-induced apoptosis is dependent on reactive oxygen species (ROS) production. It also induces uncoupling of mitochondria membrane potential and activation of caspase-3 and -9. |
Reference Show more | 1. Hu, Fangli, et al. "Fast determination of isomeric triterpenic acids in Osmanthus fragrans (Thunb.) Lour. fruits by UHPLC coupled with triple quadrupole mass spectrometry." Food chemistry 322 (2020): 126781.https://doi.org/10.1016/j.foodchem.2020.126781 2. [IF=7.514] Fangli Hu et al."Fast determination of isomeric triterpenic acids in Osmanthus fragrans (Thunb.) Lour. fruits by UHPLC coupled with triple quadrupole mass spectrometry."Food Chem. 2020 Aug;322:126781 3. [IF=4.616] Xiaoyan Liao et al."A HPLC-MS method for profiling triterpenoid acids and triterpenoid esters in Osmanthus fragrans fruits."Analyst. 2019 Nov;144(23):6981-6988 4. [IF=4.379] Zhang Liang-Liang et al."Chemical composition, antibacterial activity and action mechanism of different extracts from hawthorn (Crataegus pinnatifida Bge.)."Sci Rep-Uk. 2020 Jun;10(1):1-13 |
biological activity | , was isolated from eucaphis Japan. Randialic acid A inhibits the growth of tumor cells and induces apoptosis. Randialic acid A (Pomolic acid) has potential for prostate cancer.|
Target | IC50: apotosis |